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Differential Effects of Iron Chelates vs. Iron Salts on Induction of Pro-Oncogenic Amphiregulin and Pro-Inflammatory COX-2 in Human Intestinal Adenocarcinoma Cell Lines.
Agata Tarczykowska, Niklas Engström, Darja Dobermann, Jonathan Powell, Nathalie Scheers
Apr 17, 2023
We previously showed that two iron compounds that are orally ingested by humans, namely ferric EDTA and ferric citrate, can induce an oncogenic growth factor (amphiregulin) in human intestinal epithelial adenocarcinoma cell...
Iron IL-6 IGF1R COX-2 amphiregulin IFNGR1 ferric pyrophosphate Cell Line Humans Adenocarcinoma Iron Compounds Ferric Compounds Salts Edetic Acid Interleukin-6 Iron Chelating Agents Signal Transduction STAT Transcription Factors Cyclooxygenase 2 Janus Kinases Biomarkers
Published by: International journal of molecular sciences
Association between temporal patterns of baroreflex sensitivity after traumatic brain injury and prognosis
Agnieszka Uryga, Magdalena Kasprowicz, Małgorzata Burzyńska, Agnieszka Kazimierska, Marek Czosnyka, Nathalie Nasr
Apr 14, 2023
INTRODUCTION: Traumatic brain injury (TBI) may lead to an increase in intracranial pressure (ICP) as well as impairment of cerebral vascular reactivity and the autonomic nervous system. This study aimed to investigate individual...
In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution.
Anja Fischer, Robert Lersch, Niklas de Andrade Krätzig, Alexander Strong, Mathias J Friedrich, Julia Weber, Thomas Engleitner, Rupert Öllinger, Hsi-Yu Yen, Ursula Kohlhofer, Irene Gonzalez-Menendez, David Sailer, Liz Kogan, Mari Lahnalampi, Saara Laukkanen, Thorsten Kaltenbacher, Christine Klement, Majdaddin Rezaei, Tim Ammon, Juan J Montero, Günter Schneider, Julia Mayerle, Mathias Heikenwälder, Marc Schmidt-Supprian, Leticia Quintanilla-Martinez, Katja Steiger, Pentao Liu, Juan Cadiñanos, George S Vassiliou, Dieter Saur, Olli Lohi, Merja Heinäniemi, Nathalie Conte, Allan Bradley, Lena Rad, Roland Rad
Apr 17, 2023
In contrast to mono- or biallelic loss of tumor-suppressor function, effects of discrete gene dysregulations, as caused by non-coding (epi)genome alterations, are poorly understood. Here, by perturbing the regulatory genome in...
Circulating proteins to predict COVID-19 severity
Abstract Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully understood. To approach this problem, we measured 4701 circulating human protein abundances...
Chen-Yang Su, Sirui Zhou, Edgar Gonzalez-Kozlova, Guillaume Butler-Laporte, Elsa Brunet-Ratnasingham, Tomoko Nakanishi, Wonseok Jeon, David R Morrison, Laetitia Laurent, Jonathan Afilalo, Marc Afilalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Meriem Bouab, Louis Petitjean, Charlotte Guzman, Xiaoqing Xue, Chris Tselios, Branka Vulesevic, Olumide Adeleye, Tala Abdullah, Noor Almamlouk, Yara Moussa, Chantal DeLuca, Naomi Duggan, Erwin Schurr, Nathalie Brassard, Madeleine Durand, Diane Marie Del Valle, Ryan Thompson, Mario A Cedillo, Eric Schadt, Kai Nie, Nicole W Simons, Konstantinos Mouskas, Nicolas Zaki, Manishkumar Patel, Hui Xie, Jocelyn Harris, Robert Marvin, Esther Cheng, Kevin Tuballes, Kimberly Argueta, Ieisha Scott, Celia MT Greenwood, Clare Paterson, Michael A Hinterberg, Claudia Langenberg, Vincenzo Forgetta, Joelle Pineau, Vincent Mooser, Thomas Marron, Noam D Beckmann, Seunghee Kim-schulze, Alexander W Charney, Sacha Gnjatic, Daniel E Kaufmann, Miriam Merad, J Brent Richards
Apr 17, 2023
Overview of the DESI Milky Way Survey
Andrew P. Cooper, Sergey E. Koposov, Carlos Allende Prieto, Christopher J. Manser, Namitha Kizhuprakkat, Adam D. Myers, Arjun Dey, Boris T. Gänsicke, Ting S. Li, Constance Rockosi, Monica Valluri, Joan Najita, Alis Deason, Anand Raichoor, M.-Y. Wang, Y.-S. Ting, Bokyoung Kim, Andreia Carrillo, Wenting Wang, Leandro Beraldo e Silva, Jiwon Jesse Han, Jiani Ding, Miguel Sánchez-Conde, Jessica N. Aguilar, Steven Ahlen, Stephen Bailey, Vasily Belokurov, David Brooks, Katia Cunha, Kyle Dawson, Axel de la Macorra, Peter Doel, Daniel J. Eisenstein, Parker Fagrelius, Kevin Fanning, Andreu Font-Ribera, Jaime E. Forero-Romero, Enrique Gaztañaga, Satya Gontcho A Gontcho, Julien Guy, Klaus Honscheid, Robert Kehoe, Theodore Kisner, Anthony Kremin, Martin Landriau, Michael E. Levi, Paul Martini, Aaron M. Meisner, Ramon Miquel, John Moustakas, Jundan J. D. Nie, Nathalie Palanque-Delabrouille, Will J. Percival, Claire Poppett, Francisco Prada, Nabeel Rehemtulla, Edward Schlafly, David Schlegel, Michael Schubnell, Ray M. Sharples, Gregory Tarlé, Risa H. Wechsler, David H. Weinberg, Zhimin Zhou, Hu Zou
Apr 18, 2023
We describe the Milky Way Survey (MWS) that will be undertaken with the Dark Energy Spectroscopic Instrument (DESI) on the Mayall 4 m telescope at the Kitt Peak National Observatory. Over the next 5 yr DESI MWS will observe...
Published by: The American Astronomical Society